THE PROKARYOTIC UBIQUITIN-LIKE PROTEIN PRESENTS POOR CLEAVAGE SITES FOR PROTEASOMAL DEGRADATION

Summary: In an event reminiscent of eukaryotic ubiquitination, the bacterial prokaryotic ubiquitin-like protein (Pup)-proteasome system (PPS) marks target proteins for proteasomal degradation by covalently attaching Pup, the bacterial tagging molecule.Yet, ubiquitin is released from its conjugated target following proteasome binding, whereas Pup en

Background: A water extract (CAW) of the Ayurvedic plant Centella asiatica administered in drinking water has been shown to improve cognitive deficits in mouse models of aging and neurodegenerative Proline (L-Proline) diseases.Here the effects of CAW administered in drinking water or the diet on cognition, measures of anxiety and depression-like be